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Course: MCAT > Unit 2
Lesson 1: Foundation 1: Biomolecules- What is this passage set and how is it organized?
- How to use this passage set
- Amino acids: Dietary supplements and the mTOR pathway
- Enzyme kinetics: Forms of hexokinase
- Enzyme kinetics: NTKase and NTKase deficiency
- Enzyme kinetics: Phenylalanine hydroxylase and phenylketonuria
- Enzyme study: PMM/PGM and its substrates
- Protein expression: RbAp48 and age-related memory loss
- Gene expression: STAT3 and RORγT in hyper IgE syndrome
- Gene expression (prokaryotes): the lac operon model
- Gene expression (prokaryotes): additional lac operon practice
- Gene expression: Investigating families with hormone deficiencies
- DNA replication: Kinetics and thermodynamics of base mismatch
- DNA replication: The "speed" of DNA polymerase
- DNA technology: Genetic recombination and conditional knockouts
- DNA technology: DNA cloning using an E. coli vector
- DNA technology: RT-PCR analysis of POMC cDNA
- Chromosomal abnormalities: Translocations in the germline
- Gene mutation: IDH mutation in glioblastoma
- Gene mutations: Types of muscular dystrophy
- Genetics: Mendelian inheritance of immunodeficiency disorders
- Genetics: Mutations in Parkinson disease pathology
- Genetics: Inheritance and expression of Marfan syndrome
- Genetics: Crosses between flowering plants
- Genetics: The evolution of gecko toepads
- Genetics: Cancer-causing NF1 mutations in mice
- Bioenergetics: Phosphoryl group transfers and ATP hydrolysis
- Cellular effects of metformin, a drug for diabetes mellitus
- Metabolism: The pentose phosphate pathway and G6PD deficiency
- Metabolism: The structure and function of glycogen
- Metabolism: The carnitine shuttle and fatty acid metabolism
- Metabolism: Enzymes and reactions involved in fermentation
- Metabolism: Acetyl-CoA and fatty acid synthesis
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What is this passage set and how is it organized?
Google ClassroomThis article introduces this passage set, which covers topics from Foundation 1 of the MCAT. It also discusses how the Foundation 1 passages are organized by topic, roughly in line with the AAMC blueprint.
The passages you’ll find in this set cover biology and biochemistry topics from AAMC Foundation 1. This foundation, along with Foundations 2 and 3 (tested in the passage sets below this one), is part of the Biological and Biochemical Foundations of Living Systems section of the MCAT. Foundation 1 covers topics in biochemistry, gene expression, genetics/heritability, and bioenergetics/metabolism, whereas Foundation 2 covers topics in cell biology, and Foundation 3 covers human organ systems (anatomy and physiology).
This statement by the AAMC describes the significance of Foundation 1 topics for pre-medical students: “Biomolecules have unique properties that determine how they contribute to the structure and function of cells, and how they participate in the processes necessary to maintain life.” Accordingly, many of the MCAT passages in this section test you on the structure and function of biomolecules as well as the biomolecular processes and principles that drive cellular processes and support life.
Passages in this set are labeled with topics that roughly align with those listed in the AAMC Biological and Biochemical Foundations blueprint, under Foundation 1. The passages are also organized by topic, in an order consistent with the AAMC blueprint. The topic of each passage is indicated by its subtitle, as circled below.
Here is a list of our Foundation 1 passage topics and their corresponding AAMC content categories:
Content Category 1A: Structure and function of proteins and their constituent amino acids
- Amino acids
- Enzyme kinetics
- Enzyme study
Content Category 1B: : Transmission of genetic information from the gene to the protein
- Protein/gene expression
- DNA replication
- DNA technology
Content Category 1C: Transmission of heritable information from generation to generation and the processes that increase genetic diversity
- Chromosomal abnormalities
- Gene mutation(s)
- Genetics
Content Category 1D: Principles of bioenergetics and fuel molecule metabolism
- Bioenergetics
- Metabolism
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