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MCAT
Course: MCAT > Unit 11
Lesson 3: Behavior and geneticsHeritability
Created by Ryan Scott Patton.
Want to join the conversation?
- if we took four genetically identical children and raised them in barrels like the Mark Twain example in the video, would they have no differences in IQ?(13 votes)
- Correct. Both their genetics and environment would be exactly the same. This means that their IQ would be 100% heritable, thus 100% dependent on their genome. If you want to get more complicated, their epigenomes would not necessarily be the same however (we see differences in epigenomes just from having different placentas or amniotic sacs in utero), so that could confound the example.(12 votes)
- Why isn't h^2 for all homozygous twin studies 0 then? Because they share 100% genes so surely all the difference is attributable to the environment?(2 votes)
- When the speaker says "h two" does he mean "h squared"?
h = the % variation of traits due to genes
h^2 = (the % variation of traits due to genes)^2(1 vote) - So taking a big stab at this:
Is h^2 (the amount of variance attributed to genetic material), similar to r^2, the statistical variable identifying how variation can be explained by a graph?
Also, can someone explain r^2 for me?
Thank you so much for your help!(1 vote) - Can someone also clarify what Ryan means from- 1:04? 1:50(1 vote)
- to be sure that I have this right, are you saying, for example, that the difference in IQ between two people is 50% a result of their genetic differences (variation)?(1 vote)
- CAN ANYONE PLEASE HELP ME OUT
At 1.00, he said IQ is 50 percent heritable. This does not mean IQ is 50 percent genetic; difference in intelligence is 50 percent attributable to variation in genes.
When talking about variation, we are talking about the differences between individuals in a given study. So, the similarities between individuals are not accounted. For this reason, we cannot say that 50 percent of the IQ in an individual is caused by differences in genes. What we can say is that 50 percent of the variation in IQ between individuals can be explained by differences in genes.
As a result, heritability studies can only tell us the extent to which differences in genes are responsible for variation in a trait between individuals; and not how much each genes contribute to a given trait individually.
Is this line of reasoning correct or incorrect? If incorrect, can you please explain why.(1 vote) - If you had four quadruplets with exactly the same genome and raised them in controlled environments so that their environment was exactly the same, would they be identical?(1 vote)
- Yes, if they all share the same genome, then they will be identical quadruplets. And since they share the same environment, there would be less variation in terms of different genes being expressed.
Also, interestingly, quadruplets can vary. You can either have all 4 babies be different from each other (i.e 4 eggs were each fertilized by a different sperm). You can have all 4 babies be identical (i.e. one egg was fertilized by a sperm, and then splits three times to form 4 embryos). And then a few other combination such as 3 identical triplets + 1 more (i.e 2 eggs were fertilized, but one of the eggs split twice to form the identical triplets). Or identical twins + 2 others (i.e 3 eggs were fertilized, and one egg was split once to get the identical twins).(1 vote)
- Okay I understand this but , Fertal twins raised together and are close v.s. Identical twins raised apart but grow to be best friends, we see a strong commute here but they grow up not seeing eachother through the eyes that they should of , What would happen if they grow up never learning they were twins? And the children they have don't know that their close cousins.(1 vote)
- That would be a very rare case. And, I believe you meant to type in "Fraternal or Fertile " instead of "Fertal twins". I don't really see the problem if twins grow/grew up in different places.Perhaps if you rephrased your question, I could give you a better answer. Though right now I'm confused on what you mean.(0 votes)
- For quadruplets raised in the different environments, I understand that based on the equation, heritability would increase. However, conceptually I do not get it. Conceptually, I think of heritability as the likelihood to inherit a specific trait. Is this a wrong way to look at it conceptually?(1 vote)
- There is no wrong in looking at it conceptually.Though be sure to understand the facts.(0 votes)
Video transcript
OK. So I ended the last video,
the one on twin and adoption studies, with some
pretty specific language. I said that through
those studies, psychologists could estimate
the extent to which variation of traits, or attributes,
for any given population-- the extent to which
that variation can be attributed to
differences in genes. And I used that language,
that specific language because I was actually defining
the term "heritability." So a textbook might define
the term heritability as the proportion of
variation-- so a percentage, because a proportion is just a
percentage-- among individuals that we can attribute to genes. So I'll write "due to genes." And so I know that
even at this point, that definition is
probably not very clear. And we're going to spend the
entirety of this video just trying to clarify this concept. And so assume that we're
talking about intelligence. And we say that heritability
of intelligence is 50%, so IQ. And we've said that the
heritability is 50%. And so what we're not saying
is that the intelligence is 50% genetic. That's what we're not saying. Really, what we are saying
is that the difference in intelligence can
be accounted for or is 50% attributable to
the genetic differences. So we're talking about the
differences in these traits. Because really to ask how
much of our intelligence is mandated by our
genome as opposed to instilled in us
by our environment is completely inappropriate. And that's what we learned in
that tea and hot water example. But what can be answered and
what those twin and adoption studies started to show
us is the percentage of the different, or
variance, right here that's attributable to
the differences in genes. So I know I've said
that several times. And let me move to an example. One of my favorite
examples of heritability actually comes from Mark Twain,
the famous author and comedian. And he said that suppose you
raised four boys in barrels until they were 12 or so. So I've drawn some barrels here. And we've got four
boys inside of them. And we'll feed
them through a hole so that they get the
same diet and such. And we'll remove all
of their waste products on the same schedule. And their environments
will be 100% controlled, almost sadistically controlled,
but 100% controlled. By the age of 12, their IQs
would probably be pretty low compared to the
population around them. But the kicker is
that they're probably not all going to
be the same, right? So the differences
in their intelligence couldn't be attributed
at all to the environment because we've absolutely
controlled their environment. And we would say that their IQ
differences were nearly 100% heritable because their
environments were nearly 100% the same. So h2 is just short
for heritability. And we give it a lower
case because we're talking about one
specific trait, in this case intelligence
as opposed to many traits. But the heritability
would be close to 100%. And so that was Mark Twain's
example of heritability. But alternatively, you
could say that maybe you have four identical quadruplets
with exactly the same genome. And you raise them in crazy,
different environments. And so maybe one is raised in
the rain forest as a tribesman. And then maybe one is raised
in the desert as a nomad. And then maybe one is raised
in a North American family as maybe an industrial worker or
at least in an industrial kind of blue-collar family. And then maybe one we'll just
say is raised in outer space. He's raised up
here near the Moon, maybe on the International
Space Station. But the heritability of the
intelligence of these four boys would be quite a bit lower
because now their environments are counting for a bigger
percentage of the differences in their intelligence. And I've said here that the
heritability is actually 0% because we've
established that they're identical quadruplets. So genetically they're the same. And their environments
are completely different. So we would say that
all of the differences in their intelligence
must be attributed to their environments. So maybe a nice, oversimplified
way to think about this idea is that as the
environment becomes more and more controlled,
like in the example of the boys in the
barrels, differences in behavioral traits are more
closely tied to heredity. And the heritability of that
trait is therefore higher. And then maybe
another thing that might increase
heritability would be increased genetic
variation that leads to different phenotypes. So if there was more genetic
variation in these boys, say maybe if they were
fraternal quadruplets instead of identical
quadruplets and they had different genotypes and
more genetic variation leading to different phenotypes or just
the expression of their traits, those new variations would be
more related to their genes. So in this case, again, the
heritability would increase. And so heritability
is either increasing because genetics are
contributing more to the genes or because nongenetic
factors, like the environment, are contributing less. But what matters is
that we're talking about the relative
contribution of genes to the variation in
behavior or traits. And so you might
have just caught on that heritability
then becomes necessarily dependent on the
population that's studied. And so think about
one last time, the population of boys
inside the barrels. Their heritability
is much higher-- or the heritability of their
IQ rather is much higher than it would have
been if we had instead studied the quadruplets. So one last time,
heritability of a trait is the extent to which variation
can be attributed to genes. And it's very, very
dependent on the populations and the environments
that we study. But hopefully,
that just gives us a quick context for
what we mean when we use this word in the future.