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Drug dependence questions


The drug disulfiram works by antagonizing acetaldehyde dehydrogenase by binding to copper ions. This prevents the liver from breaking acetaldehyde into acetic acid. Individuals with a gene variant that causes slower metabolization of acetaldehyde are more likely to experience adverse effects from a buildup of acetaldehyde. It has been shown that about half of the people in China and Japan have this gene. What effect could this have on the culture of alcohol abuse in China and Japan?
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