If you're seeing this message, it means we're having trouble loading external resources on our website.

If you're behind a web filter, please make sure that the domains *.kastatic.org and *.kasandbox.org are unblocked.

Main content
Current time:0:00Total duration:10:11

Neuron graded potential mechanism

Video transcript

in this video I want to talk about how neuron graded potentials are created and why they decay with both time and distance so I've again drawn a neuron with a soma and red and I've blown up an axon in green and I've blown up to large dendrites in blue and here's our graph looking at the membrane potential on the y-axis I put in a few values in millivolts negative 50 negative 60 and negative 70 you'll have time on the x-axis so now recall that a resting neuron without inputs has a layer of positively charged ions on the outside of the membrane and a layer of negatively charged ions on the inside of the membrane and that the strength of that charge separation without inputs may vary between neurons but it's often around negative 60 millivolts for the resting potential and recall that neurons have a threshold potential that's often around negative 50 millivolts so that if the membrane potential at the trigger zone passes the threshold potential an action potential may be fired down the axon and recall that with inputs the resting potential of neurons may be moved by a small brief potential changes that we call graded potentials that may move the membrane potential closer to zero which we call a depolarization or an excitatory potential or which may move the membrane potential away from zero and farther away from threshold which we call a hyper polarization or an inhibitory potential now to understand how these graded potentials occur I need to introduce a new type of ion channel which I've drawn here and these are neurotransmitter receptors neurotransmitter receptors are found at synapses where the axon terminal of another neuron where neurotransmitter molecules are released into the synapse and they bind to these neurotransmitter receptors many neurotransmitter receptors are a type of ligand gated ion channel which means that unlike the leak channels that we talked about before which are always open these channels are gated they're closed most of the time until their ligand which in this case is a neurotransmitter binds to the receptor and then the ion channel opens and ions may pass across the membrane through the channel the graded potentials that are produced depends on way types of ions are allowed to pass because some of these allow only one type of ion to pass while others allow multiple types of ions to pass it also depends on how many channels are opened which depends on the amount of neurotransmitter released into the synapse and it depends on how long the channels stay open which depends on how long your transmitter stays in the synapse to continue binding to the neurotransmitter receptor if a channel opens that is selective for only one type of ion the membrane permeability for that ion is increased which causes the potential of the membrane around the channel to move toward the equilibrium potential of that ion and recall that an equilibrium potential is the membrane potential at which a certain ion will have balanced electrical and diffusion forces so that even if there are open channels there is no net movement of that ion if the channel is a sodium channel or a calcium channel opening of that channel will usually cause a depolarization and excitatory potential because these cations will usually flow into the neuron bringing positive charges into the negative inside of the neuron causing a depolarization because for sodium and calcium both their electrical force and their diffusion force are trying to drive them into the neuron if there are open channels through which they can pass hyper-polarization usually occurs if a chloride channel is opened because for most neurons chloride will flow into the neuron through an open channel bringing negative charges into the already negative inside of the cell causing the membrane potential to become more negative and that's because for most neurons chloride has a larger diffusion force driving it into the neuron against its smaller electrical force that's trying to drive it out of the neuron hyper-polarization may also occur if a potassium channel opens because for potassium ions it's larger diffusion force will usually drive it out of a neuron against its smaller electrical force trying to drive it into the neuron let's look at one of these channels a little bit more closely and see what's happening to the ions when neurotransmitter binds to the receptor and the channel opens to the ion let's first consider a sodium channel so let's say this neurotransmitter ion channel when neurotransmitter binds it opens and it only allows sodium ions to flow into the neuron now as these sodium ions are flowing through this open channel there will be an increased concentration of sodium in a small area right around the channel and as these positive charges are building up on the inside of the membrane around the channel that's depolarizing this part of the membrane so let me actually write that so this piece of the membrane then what we're gonna see is that the membrane potential starts to move to a less negative value but then the question is why does this stop why doesn't the membrane potential just keep climbing from here well the first thing that happens is that the neurotransmitter will leave the receptor it will become unbound to the receptor and without neurotransmitter bound the ion channel will close so it's no longer allowing positively charged sodium ions to flow into the neuron so that's gonna cause the graded potential to kind of plateau it's gonna stop growing at that point but then why does it decay why why do these graded potentials only last a short time and decay with time well the reason for this is that this little area right here where there's a high concentration of sodium ions isn't going to stay like that because all of these sodium ions are acted on by electrical and diffusion forces inside the cytoplasm just like they are when we're talking about them across the membrane the diffusion force is going to want them to go from areas of high concentration to areas of lower concentration and the electrical forces is also going to want that these positively charged ions are gonna want to get as far away from each other as they can because like charges repel each other so these sodium ions that came into the open channel are gonna go racing off in every direction to get as far away from each other as they can and they'll just mix in with all the other ions through the cytoplasm until they are as far away from each other as they can and then they're in equilibrium and the cytoplasm has an enormous total number of sodium ions compared to the very small number that came through this open channel during the brief time that it was so because this small area of increased concentration of sodium ions isn't going to last all these sodium ions are going to race away from each other the depolarization of this piece of the membrane is not going to last either and this is gonna be the decay that happens with time that piece of membrane is just gonna go right back to the resting potential once all these sodium ions spread out and equilibrated through the rest of the cytoplasm imagine this as a small hemisphere of increased sodium concentration on the inside of the membrane centered on the open channel this hemisphere rapidly expands in all directions away from the channel on the inside of the membrane weakening as it expands and as these sodium ions are getting farther away from each other until it eventually fades away entirely as the sodium equilibrates with the sodium and the rest of the cytoplasm as this little hemisphere of increased sodium ion concentration expands away from the channel weakening as it expands a wave of depolarization starts spreading across the membrane away from the open channel and that wave of depolarization is also weakening as it spreads so that right here it might be a certain size if we look at this piece of membrane maybe it's about that size but as it's kind of spreading across the membrane if we check in with it a little farther away it has weakened it has decayed and as it continues spreading along the membrane and these sodium ions are spreading farther and further apart the depolarization gets smaller and smaller so that the graded potential degrades with distance just like it degrades with time so this is the way the graded potentials degrade with time and degrade with distance so that their effects are only additive if they occur close enough together in time and in space the most common cause of an excitatory graded potential in neurons is entry of sodium ions through neurotransmitter receptors that allow sodium ions to pass when the neurotransmitter is bound but the mechanism would be the same for calcium ions they also would flow into the neuron bringing their positive charges in which would then rapidly spread out in every direction causing it potential the most common cause of inhibitory potentials in neurons is entry of chloride ions through neurotransmitter receptors that allow chloride ions to pass and the mechanism is really the same but because chloride is an anion we're gonna have a little buildup of negative charges affecting the membrane potential around the channel making it more negative and then the diffusion forces and the electrical forces will cause the chloride ions to spread out to try to equilibrate in the rest of the cytoplasm so that a hyper-polarization caused by chloride ion entry through a neurotransmitter receptor will also decay with time and with distance inhibitory potentials may also occur if a neurotransmitter receptor allows potassium ions to exit the neuron the mechanism of this is really the same as well but now we have a collection of positive charges around the open channel on the outside of the membrane so that makes the positive outside even more positive which is the same thing as saying that the inside of the membrane is more negative so you get a hyper polarization and then this little area of increased potassium ion concentration will rapidly dissipate out but in this case it's dissipating into the interstitial fluid outside of the neuron as opposed to the cytoplasm inside the neuron