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Neuron graded potential description

Created by Matthew Barry Jensen.

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  • leafers seedling style avatar for user Louisa Larocque
    I'm confused about what temporal summation and spatial summation are.
    At you call the adding of effects temporal summation, when two graded potentials happen at the same time, but at you call it spatial summation. May you please clarify?
    (22 votes)
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    • piceratops seed style avatar for user Jorge Barquin
      Temporal summation is when the stimulus is applied repeatedly in rapid succession. For example, 1 stimulus raises the charge from -60 mV to -58 mV, then another quickly comes in and raises it from -58 mV to -56 mV and so on until, lets say, threshold is reached at -40 mV and an action potential is fired. So you are getting multiple stimuli back-to-back for a period of time.

      Spatial summation refers to stimuli from different sources occurring at a similar time. So now you are getting 4 stimuli occurring at once, each of them capable of raising the charge 5 mV. So within that one msec that they all occur, the charge shoots up from -60 mV to -40 mV and now the action potential is fired in that way. So you are getting multiple stimuli at the same time.

      In simpler terms, temporal summation refers to frequency of stimuli. Spatial summation refers to the number of stimuli.
      (47 votes)
  • leaf green style avatar for user Dawn Horan
    Is the trigger zone the same as the axon hillock?
    (15 votes)
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  • blobby green style avatar for user maryam.mohamma
    I was taught that the resting membrane potential was -70 mV for most cells, not -60 mV. Can you please explain?
    (11 votes)
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    • piceratops ultimate style avatar for user ILoveToLearn
      Yes, the avg. resting potential is -70mV, although estimates vary. Just stick with -70. -60 is just another estimate, and as many estimates covering a relatively wide range are out there, stick with what you've been taught.
      I agree firmly with you. My neuroscience cards use -70. It's just an estimation difference. I've seen a rather large variance in estimates.
      (11 votes)
  • orange juice squid orange style avatar for user Abraham George
    Where would the cytoplasm, nucleus, and all the other organelles be in this diagram?
    (5 votes)
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    • piceratops ultimate style avatar for user Alexander Yang
      Like other cells, the cytoplasm is continuous within all parts of the neuron. The nucleus and most organelles are localized within the cell body...

      Some organelles and other macromolecules are, however, also transported from the cell body "down" the axon toward the synapse (and sometimes back). This process, called axonal transport, is achieved with the help of microtubules (which act similar to train tracks) and associated motor proteins (which do the "walking" down the microtubules). This actually serves an important role for transporting things like mitochondria, synaptic vesicles (w/ neurotransmitters), and many other proteins (e.g. enzymes and proteins needed for vesicle fusion, etc.).

      Some neurons have incredibly long axons, such as the neurons that make up the sciatic nerve. The sciatic nerve (and the continuous branches off of it) runs down the length of your leg. For example, pretend you ARE that neuron. Think about how ANGRY you would be if you had to wait for the ATP made in your cell body to diffuse all the way to the end of your axon, instead of just sending a few mitochondia down there and making ATP "on site."

      Idk. Personally, I'd be grumpy... And, the fact that impaired axonal transport is implicated in some neurodegenerative diseases leads me to believe that other neurons agree.
      (14 votes)
  • marcimus pink style avatar for user Cailen
    So do synapses occur at the cell soma too ()? I thought they could only happen at the dendrites
    (5 votes)
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  • mr pink red style avatar for user habin
    Are graded potentials the same thing as electrotonic potentials?
    (6 votes)
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  • purple pi purple style avatar for user Erin
    So, is the point of graded potentials just to determine whether or not we will have an action potential?
    (3 votes)
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    • leaf green style avatar for user Joanne
      Yes. The 'average' neuron has 1000 neurons that synapse on it and tell it what to do by creating graded potentials. Some are excitatory ( depolarizing) and some are inhibitory (hyperpolarizing). If the sum of the graded potentials cause the membrane at the axon hillock to reach threshold, then this 'average' neuron will have an active potential. Frankly, it is amazing.
      (8 votes)
  • primosaur sapling style avatar for user David Mayrose
    Is this really what a neuron looks like or is it simply a model used for explanatory purposes?
    (1 vote)
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  • blobby green style avatar for user Bloods
    why are two added depolarizations longer, and not only stronger, than one?
    (2 votes)
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    • orange juice squid orange style avatar for user Madeleine Howard
      Since action potentials are achieved by reaching a threshold, there is no way to reach a stronger action potential just from having a "stronger" depolarization. It isn't possible to have a stronger action potential on one neuron, there is just one type when it reaches threshold. The only way to achieve a stronger change in the brain would be to fire several action potentials on the same neuron close together in time (temporal summation) or to fire an action potential on several neurons that are nearby at the same time (spatial summation).
      (3 votes)
  • primosaur ultimate style avatar for user dannylop222
    If two hyperpolarizations happened at the same time, would that lead to a depolarizations, because two negatives lead to a positive?
    (1 vote)
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Video transcript

In this video, I want to describe the graded membrane potential changes that occur in neurons in response to input, which we just call graded potentials, for short. So I've drawn a blown-up neuron here. We have a soma in red, and an axon in green, and two dendrites in blue. And recall that resting neurons-- that is, neurons that aren't receiving any input-- usually have a stable charge separation across the entire membrane, where there is a layer of positively-charged ions, also called cations, on the outside of the neuron membrane, and a layer of negatively-charged ions, also called anions, on the inside of the membrane. And that we call the outside 0, just to set it as a reference, and that the resting membrane potential of neurons may vary, but it's often around negative 60 millivolts. So let me show that on a graph, here. Let's say we're looking at this piece of membrane. And on the x-axis, we'll put time, and on the y-axis, we'll put the membrane potential in millivolts. And so let me put, right in the middle here, this negative 60 millivolts that's a common neuron resting potential. And that when the neuron is at rest, without inputs, most neurons just have a stable potential at their resting membrane potential, where it's not changing over time without input. Now, inputs from certain types of stimuli may increase or decrease the membrane potential of the neuron a small amount, for a brief time, before it returns back to the resting potential. These transient membrane potential changes are called graded potentials, and they tend to occur in the dendrites of the neuron and in the soma of the neuron. And the size and the duration of the graded potentials is determined by the size and the duration of inputs-- both excitatory inputs and inhibitory inputs. Graded potentials do not pass into the axons of most types of neurons. Instead, most axons have a different membrane potential change, called an action potential. Action potentials start at the area called the trigger zone, which is the initial segment, or the start, of the axon. And they start when the combined effect of the graded potentials at any moment in time brings the membrane of the trigger zone across a certain value called the threshold potential. So let me just draw that with a little dashed line here. And this threshold potential will vary between neurons, but somewhere around negative 50 millivolts would be a common threshold potential. So that if the membrane potential at the trigger zone can be moved from the resting potential, which is often around negative 60 millivolts, over the threshold potential, which is often around negative 50 millivolts, then a totally different potential change will happen, called the action potential, that will shoot all the way down the axon. Now this adding together of graded potentials is called summation. And summation at the trigger zone is how neurons process information from their inputs. Most neurons respond to inputs from other neurons in the form of neurotransmitter molecules that are released at synapses. So that if this is the axon terminal of another neuron, it may release neurotransmitter at the synapse where these two neurons come together, which will bind to little receptors on the membrane of this neuron-- in this case, here, on a dendrite-- and this will produce some kind of graded potential. Now we'll get into the details of this more in other videos, but this is the most common type of input that a neuron will receive. And depending on the neurotransmitter, and depending on the receptor, this may be an excitatory input, or it may be an inhibitory input. Now some other types of neurons in neuron-like cells that are sensory receptors may also generate graded potentials from physical stimuli, such as light or odorant molecules. Graded potentials produced from a synapse are called synaptic or post-synaptic potentials. And those generated by stimuli and sensory receptors are also called receptor potentials. A graded potential like this one, that moves the membrane potential to a less negative number, or closer to zero, is called a depolarization, because now the membrane is less polarized. It has less charge separation. These are also called excitatory potentials, because they move the membrane potential closer to the threshold, so they increase the likelihood that an action potential will be started at the trigger zone. A graded potential like this one, that moves the membrane potential to a more negative number, farther away from 0, is called a hyperpolarization, because it's increasing the polarization, or the charge separation, of the membrane. Hyperpolarizations are also called inhibitory potentials, because by moving the membrane potential farther from the threshold, they're decreasing the likelihood that an action potential will be started at the trigger zone. Two important properties of graded potentials are that they decay with both time and distance, so that their effect is brief and local. Graded potentials decay with time, just like I've drawn here. The membrane potential changes for a brief time, and then it returns to the resting potential, unless there is more input. And because graded potentials decay with time, if two graded potentials happen that are separated by enough time, they won't have any effect on each other. For example, let's say that this depolarization happens and is finished before a second depolarization over here occurs. Since this one was already done, already fully decayed, these two had no effect on each other. But if two depolarizations happened right around the same time, their effects can add together. They have additive effects. And you can get a depolarization twice the size. We call this process temporal summation, or adding together of graded potentials in time. Graded potentials also decay with distance, as well as with time. So let's look at this depolarization. And let me just move it over here. And let's say that this synaptic potential, or post-synaptic potential, is a depolarization. Let me say, right at this piece of membrane, we get about this size of a depolarization. As the depolarization spreads across the membrane, it's going to decay in size. So let's say, maybe, we check in with it here, at this piece of the membrane. Now it's a smaller size than it was when it started over here. And as it continues spreading across the membrane, maybe if we check in with it over here, it's now actually quite small. So that by the time it gets to the trigger zone, where the decisions are made to fire an action potential or not, the depolarization that started way over here may not have much of an effect on the membrane at the trigger zone. Similar to the concept of temporal summation is the concept of spatial summation-- that if two graded potentials happen far enough away from each other, they may have no effect on each other. For example, let's say that there's another excitatory input way down here at this dendrite, that causes a depolarization. Just like this depolarization, as this spreads across the membrane, it's going to decay, so that it'll get smaller with distance. So that maybe by the time these two reach the trigger zone, they've decayed entirely so that they have no effect on each other. But if, instead, you had two kinds of excitatory input very close to each other on the membrane, then those two depolarizations could have spatial summation. They can add together in space. So that you could get a depolarization twice the size. The same would be true for hyperpolarizations. You can have temporal and spatial summation of hyperpolarizations, to get hyperpolarizations that are larger in size. So what would happen if you had an excitatory input and an inhibitory input at the same time and place? Well, instead of getting both a depolarization and a hyperpolarization, what you may get is no change to the membrane potential. They may cancel each other out and leave the membrane potential at the resting potential. Now one effect of the fact that graded membrane potential changes decay with distance is that the closer an input is to the trigger zone, the greater effect it will have on the likelihood of an action potential being fired down the axon. Because if a graded potential starts closer to the trigger zone, it will decay less by the time it gets there than a graded potential that starts farther away and decays more with greater distance. Therefore a synapse that's closer to the trigger zone will have a greater influence on the behavior of the neuron in terms of action potentials being fired, than the synapse that's farther away. For example, here, way out at the end of a dendrite. One last thing that I want to mention is that synaptic potentials like these tend to be quite small in size. And in fact, I've drawn these too large, because they're usually less than 1 millivolt in size. Therefore most neurons require the temporal and spatial summation of many synaptic potentials to move the 10 millivolts or so that usually separate a typical resting and a typical threshold potential for any particular neuron. So that as all the different synapses that are connecting this neuron to lots of other neurons in its network are creating all these synaptic potentials, the membrane potential of the dendrites and the soma is constantly moving around and wiggling around off the resting potential, until there's enough excitatory potentials-- enough of these depolarizations-- that are being summed in space and time, to cause an action potential to be fired down the axon. So some very complex processing of information from all these inputs can occur because of these graded potentials.