The lymphatic system's role in immunity
Learn about how B and T cells reside in lymph nodes. Find out how that enables them to get a preview of what they need to be prepared to fight. By Patrick van Nieuwenhuizen.. Created by Patrick van Nieuwenhuizen.
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- Once the B cells and T cells detect a threat, how do they find the place of infection?(19 votes)
- So when we take anti biotics, are we actually activating B cells to disperse anti bodys to fight infections more effectively. Or does anti biotics kills these infections on its own or is there some other process that involves anti biotics?(1 vote)
- Is it true that lymph node massage can have an effect on your health? What if when you massage, you squeeze the fluid that is not yet filtered through the lymph node? Isnt that a bad thing?(14 votes)
- This is fascinating. Few more answers on this question would be awesome. I found something below. This states, manual lymp drainage (massage) in cases of breast cancer patents may be risky as it increases the chances of spreading of tumor cells.
- At4:17, Rishi said that these bacteria are going to get swept in. Does that mean because they're in the interstitial fluid, they get swept into the lymphatic vessels?
Also, does that mean all interstitial fluid get into the lymphatic vessels? Because if not, there might be some bacteria lurking around in fluid that has not get in.(8 votes)
- Interstitial fluid typically ends up in the lymphatic system. Not all does and, in fact, sometimes bacteria do live in the interstitial fluid instead of making their way into the lymphatics. The can form infections called "abscesses" that can be difficult for the body to clear because there is little drainage by the venous or lymphatic systems. These often have to be surgically drained. Good insight!(13 votes)
- What if the bacteria is in the cell and not in the interstitial fluid? Do they get extracted into lymph nodes or how do they get killed?(5 votes)
- they can be killed by cytoxic t-cells(cd8+t cells) or nk cells(Natural Killer Cells)(3 votes)
- Earlier, you mention that large proteins/cells do not enter the lymphatic vessels from the capillaries, only small molecules, liquid and small proteins. How do bacteria (unicellular organism) enter?(4 votes)
- bacteria is really small, some about 1/10 of an erythrocyte(3 votes)
- how come the infection will go into the lymphatic system but not a blood vessel?(2 votes)
- The lymphatic capillaries have larger floppy openings and lower pressure which allow everything from small bacteria to large cells to enter them. The body's immune cells, WBCs, use this path to travel to lymph nodes and activate the immune response, which is its normal purpose. So lymphocytes and other WBC s travel in lymph. However, since the lymph system connects to the right and left sub clavian vein, microbes and cells, including cancerous cells, can get into the blood and circulate around the body. Blood capillaries have smaller openings that hold in the cells unless there is inflammation in the region. The inflammation will dilate capillaries and allow the movement of WBC s and extra fluid from the blood into the damaged area causing swelling of the damaged area. This additional fluid and the WBC s will leave the region by way of the low pressure lymph capillaries.(6 votes)
- So you could think of the B and T cells as "police" for our immune system when we get infected with a type of bacteria or virus? I think I'm making this system concept harder than it really is.(1 vote)
- There are a lot of actors in this play! It is good to try to make it simple and add detail later, what you are saying makes sense. I like to say the Innate system cells, neutrophils, macrophages, dendritic cells, ( and natural killer cells) are the police, they are hanging out at street corners, responding to alarms and going after anyone that 'runs' or looks suspicious. The B and T cells are the officers in the Acquired Immune System, the FBI guys that only react to a wanted poster of one particular bad guy, that is the only one they will leave their coffee and doughnuts for and get to work . The police have to present the poster (antigen presenting cell) and then the B cells and T cells get to work churning out antibodies and going house to house, destroying infected cells respectively. Making it fun helps. The crash course in biology videos also help.(7 votes)
- Are there any known conditions where the person is born with fewer lymphatic vessels? If so, do they have a harder time fighting infections?(4 votes)
- How do the macrophages get into the interstitial fluid in the first place? They're too big to seep out of the bloodstream, right?(2 votes)
- Macrophages are normally found in essentially every tissue type In the body.(4 votes)
- Just to clarify, T and B cells do NOT travel to the site of infection. They are activated and fight the infection IN the lymph node?(2 votes)
- B cells do not go out to fight they stay where they are and release Anybodies(1 vote)
We've talked about how the purpose of the lymphatic system is to collect fluid that's squeezed out of blood vessels like this one-- to collect that fluid and eventually bring it back into the blood so that we don't lose too much fluid. So this is a blood vessel. Around it, we have some cells that are maybe being fed by the blood vessel. And at the same time, we have these lymphatic vessels that kind of start out of nothing. And they're porous so that they can collect the fluid that was squeezed out of the blood vessels. And then eventually, they'll put that fluid back into the blood. But the lymphatic system actually has other purposes. It helps us in other ways. And we're going to talk about one of those other ways in this video. And to talk about that, we need to talk a little bit about infection. So infection is when your body gets attacked by a foreign invader. And that invader will usually be a bacteria or a virus. And in this case, let's talk about a bacteria. So let's say we get a bacteria that invades this tissue here. So the first thing you might ask is, why am I drawing the bacteria here? Why am I drawing it outside of the blood? Maybe I should be drawing it here inside the blood. And one reason why I might think that, why you might think that, is because think about when you get infected. Sometimes, you get infected when you cut yourself, right? When you cut yourself, you might get an infected wound. And when you cut yourself, you see blood. So you might think that you're getting infected because bacteria or viruses or whatever are getting into the blood. But actually, that's not quite true. Infections are usually not in the blood. And actually, there's a pretty simple, you could say, proof of that, which is that when you get infected, infections almost always stay localized. And by that, I mean that they usually stay in one place. So think about when you get an infected cut. Usually-- let's say, it's on your finger-- the infection will stay on your finger. Or let's say you get a UTI, which is a urinary tract infection. The infection usually stays in your urinary tract. Or maybe you get pneumonia. The infection stays in your lungs. So if the infection was actually in your blood, it would immediately go all over the body. And that does happen sometimes. But it's way more serious than the majority of infections. So really, the most accurate way to draw a typical infection is to draw the infection occurring in the tissues. Now, when we have this infection, there are going to be some local immune cells that your body has that's going to be fighting these bacteria and trying to kill them. But your body also has more powerful, really, defenses, which consist of B cells and T cells. And these guys are part of the adaptive immune system, which means that they actually sort of react to the specific invader that's there. So unlike these guys here-- which, for the most part are macrophages-- unlike these macrophages, who can fight lots of different kinds of bacteria, these B cells and T cells will react to the specific bacteria and end up having a much more powerful effect against them because of that. They're specially tailored to the invader. But the problem is that these guys don't just sit out there in the tissues where the infections start. And there are a few reasons for that. But probably the most important is that for these B and T cells to specialize against these invaders requires a very complex process that couldn't possibly occur just willy-nilly out here in the tissues. They require a special environment, which we can draw here, which is kind of like a training camp where they can develop in response to this specific invader. But now, we're faced with a problem, because we've already said that these bacteria stay here in the tissues. They're not swept into the blood and then carried to the B and T cells over there. They stay in the tissues. And these B and T cells are not out there in the tissues. So how can we get these B and T cells to see these bacteria and be able to react against them? And that is precisely what this lymphatic system does, because these bacteria are going to get swept in. And at the same time, these macrophages might gobble up some of these bacteria. And once they've done that, they might migrate into these lymphatic vessels. And it turns out that the way your body resolves all this is to sweep all these things directly to the nearest lymph node. And that's what this structure is called. It's called a lymph node. It's called a node because it's generally a smallish object in your body, and it looks somewhat circular. So it's like a node. And the word lymph has to do with the fact that we have B and T cells here. And it's also convenient, because what leads to it is the lymphatic vessel. So these bacteria and some of these macrophages carrying the bacteria will get swept along. And they'll be in contact with these B and T cells, who can then multiply and specialize and get ready to fight this infection over here. And we're not going to talk about how they ultimately do that, because that's a topic, really, for another video. But I just wanted to mention that, as we said, the primary purpose, really, of the lymphatic system, of these lymphatic vessels, is to carry fluid back into the blood. So obviously, by the time all this stuff gets here to this lymph node, that can't be the end of the lymph vessel. So lymph vessel is actually going to continue. It's going to continue, and it's going to eventually carry fluid and such back into the blood. So ultimately, the fluid is going to end up back in the blood. And so actually, another nice side effect of having these lymph nodes here interspersed throughout the lymphatic vessels is that they'll actually filter all this fluid that's gonna get put back into the blood. If you didn't have this lymph node here, you would still need the lymphatic vessels to get rid of the fluid that your blood is filtering. And what would happen is these bacteria would get just put directly back into the bloodstream. And that would be a problem, because as we said, infections of the blood are way more serious than local infections of tissues. So this lymph node acts as a filter for the lymph, which is passing through here. And actually, it also has some macrophages here that are going to help gobble up some of the bacteria that might be floating through. And so in sum, I think we're left with something that's really a very elegant system. What happens is we've developed a way to sweep all these bacterial invaders basically to the nearest police station. And at the same time, we've developed a system to filter the fluid that got squeezed out of these blood vessels, to filter it as it passes through here, so that by the time it gets to the end, it's free of bacteria and other debris. So before we finish, let's talk a little bit more about these lymph nodes so we have a sense of what they're like in reality. So they're generally fairly small. They're definitely much smaller than your average organ. And so they're not considered organs. And they're about 1 to 25 millimeters. And they're small enough that you can have lots of them in your body. And so you do. You have about 600. There are about 600 in the body. And some of them are located close enough to the skin that you can feel them. And those would obviously be the bigger ones. It would be hard to feel something that's 1 millimeter. And so let's look at where some of these are located on a human body. Let's actually give this guy a neck to be generous. So the lymph nodes are, obviously, located all along lymph vessels. But because there are 600 of them, they're located along the larger lymphatic vessels that have already collected many of the little lymphatic vessels and consolidated them. So let's start with places where you might actually feel lymph nodes on your own body. So often, you can feel the lymph nodes that are in the inguinal region there, kind of between your thigh and your abdomen. And as we know, there are kind of large lymphatic vessels that consolidate here and merge and rise up the body. And all along here, you might have lymph nodes, all along there. And then often, when a doctor gives you a check up, he'll feel for lymph nodes along your clavicles there. He might feel along your neck. And he might actually feel on your face and below your jaw. So all those are along lymph vessels that are coming down. And then the lymph vessels that are coming here from your arms-- those will have lymph nodes along them. And so in this way, you have about 600 of these lymph nodes sprinkled about in your body. And the cool fact to remember is that any lymph that's coming out of any tissue in your body will pass through at least one lymph node before it goes back to your blood. So even if it's out in your little pinky finger or something, the lymph vessels that carry that back will come and join a larger lymph vessel, which will pass through a lymph node. Or even if it's here in your stomach, it'll come and it'll join, and it'll pass, and it'll get into a larger one with a lymph node. So really, all the lymph that goes back into your blood is filtered.