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5D: Aldol condensations are one of the most important, frequently seen reactions in biochemistry. In fact, the very first reaction of the Krebs (TCA) cycle is an aldol condensation in which acetyl CoA condenses with oxaloacetate, forming citrate. You will learn the mechanism of these reactions formed as we extend this concept to predict the products of aldol condensations.
Questions pertaining to alpha-carbon chemistry
Mechanisms for acid and base catalyzed keto-enol tautomerization. By Jay.
How to form enolates from aldehydes using sodium ethoxide and sodium hydride
Forming enolates from ketones using LDA and sodium ethoxide
How to form different enolates from ketones
Base-catalyzed mechanism for aldol addition and aldol condensation
How to find the product of a mixed (crossed) aldol condensation
How to direct a mixed aldol condensation using a lithium enolate
How to think about the aldol condensation using retrosynthesis
How to determine the product of an intramolecular aldol condensation