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### Course: High school biology (DEPRECATED) > Unit 3

Lesson 3: Passive and active transport# Diffusion - Introduction

Diffusion occurs when particles move from an area of high concentration to low concentration, creating a concentration gradient. This natural, energy-free process occurs due to the random movement of particles, with a higher chance of particles moving from the high concentration side. Over time, this leads to an equilibrium state with equal concentrations on both sides. Created by Sal Khan.

## Want to join the conversation?

- Because everything is probabilistic, doesn’t that mean that it is possible for me to suddenly start choking because all or most of the air molecules moved to the other side of room?(14 votes)
- I think the probability of this happening is infinitely, incomprehensibly small.(10 votes)

- How does water go through the cell membrane?(6 votes)
- Water cannot go through the cell membrane by itself, but there are carrier proteins like aquaporins that can let water to pass through in a process called facilitated diffusion.(12 votes)

- Is passive transport the same as diffusion? If not, what is the difference?(3 votes)
- Diffusion is
*a type*of passive transport.

There are 4 types of passive transport in total: simple diffusion, facilitated diffusion, filtration, and osmosis.(11 votes)

- in one of the explanations of diffusion, it says a "net movement," so what's the meaning of the net movement?(5 votes)
- It is a sum of the particles moving in both directions.

Let set them aside.

You have particles moving from A to B

and from B to A.

Whether does diffusion is from A to or from B to A depends on the net movement.

Let's say 13 particles move from A to B and 11 from B to A.

What is the net movement? :D(4 votes)

- What is higher concentration and lower concentration?(3 votes)
- Higher concentration means that you have more of something on one side and the other side. Lower concentration means you have less of something on one side than an other side. Hope this helps :)(6 votes)

- Are concentration gradients only present in forms of passive transport. If yes, are they present in ALL passive-transport types?(5 votes)
- No! concentration gradients are there, but the real thing that happens is either passive or active transport. In the previous Sal shows us that by applying energy we can prevent molecules by going with the gradient and going against it! And second also No! because there are also Electrical gradients and many more, Passive transport also happens in these!(2 votes)

- What is the difference between osmosis and diffusion? Or is osmosis a kind of diffusion?(3 votes)
- Osmosis is a kind of diffusion. Diffusion is the movement of substances from a high to low concentration, while osmosis is the diffusion of water across a cell membrane that moves from high to low water potential (or, low solute concentration to high solute concentration).(6 votes)

- It is like if you were playing poolball, but all the balls were randomly placed(5 votes)
- If there is no gradient, and there is an equal chance that the particles will move either left or right, then how do gradients occur in the first place?(4 votes)
- It's not that everything is perfect from the beginning! and if there is energy given to that equilibrium it can also become a gradient again! So that is one way I know of and that is if we apply energy to have an Active transport. In that case, there will be no equilibrium!(2 votes)

- Because the molecules are constantly bouncing around, does that mean that the side that has the most concentration is constantly changing?(2 votes)
- In a way yes, however eventually, they will reach equilibrium, where both sides are changing concentration at the same rate. But, if you were able to track each and every molecule, the sides would be different, but close.(5 votes)

## Video transcript

- Let's say that I have this green container and inside this green container I have some air molecules. Now the air molecules, we assume that there's some temperature, there's some average kinetic energy to them but they're all going to have different velocities, they're all going to be bumping around in different ways. Now the way that I've drawn it you might notice something. On the left hand side, and I'll just draw an imaginary line here, this line has no, no real, I guess you could say structural significance, it's not like it's actually dividing it, I'm just using it to visualize the left and right hand sides. You see on the left hand side I have a higher concentration of my molecules, higher concentration, and how do you measure concentration? Well the number of molecules per, well the real way that you should do it is unit volume but we're looking at a cross section here. If I were to take a section that large, look, I got four molecules here, looks like I have about four, three to five molecules per section around that size, well if I took a that size section on this side I'm getting one or maybe two molecules. And I'm not going to get too precise but it's clear that I have a higher concentration here, I have more molecules that we have drawn at per unit area but if we're thinking in three dimensions, per unit volume, than we have on the right hand side. So we have a higher concentration on the left, we have a lower concentration on the right, lower concentration on the right. And when you have this situation where you have a higher concentration and then a lower concentration, we call this a concentration gradient. The concentration is changing from high to low and so we call this a concentration, concentration... concentration gradient. Now what do we think is going to happen? Let's say this is, this is what our situation is right when we look at it, what do we think is going to happen? Well these, all of these particles are all going to be bouncing around, things get moved from the left to the right, things get moved from the right to the left, but we have more particles on the left that are likely to move to the right than we have particles on the right that are likely to move to the left. Remember, they're all moving in different directions with these random velocities but I have more on this side and they're all bouncing around so in any given moment when we have this higher concentration on the left I have a higher chance that I'm going to have stuff go from the left to the right, go from the left to the right, than I do from the right to the left, and so as time goes on, as time goes on it's going to look something like this. If we let this system stabilize, if we let this system stabilize for awhile it should look like this. Now let me see if I can do a good job, a good job drawing it, and I'll just draw the molecules, I won't draw their actual, their actual velocity vectors. So if we wait awhile, how many molecules did I have, one, two, three, four, five, six, seven, eight, nine, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, so now I have one, two, three, four five, six, seven, eight, nine, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20. So if we let enough time go by we see that we don't, we should no longer have a concentration gradient, that the concentration should be fairly uniform over time. So even if I were to draw that imaginary dashed line, if I were to draw that imaginary dashed line, I should have the same concentration on both sides so I no longer have a gradient, I have no gradient, and once again there's nothing magical here, it's not like the molecule said, "Oh, we are less "concentrated over there, I somehow have to know "to move there," you just have to think that these are all just randomly bouncing around and if you have a higher concentration on the left there's a higher chance that you have bounces or you have things moving from the left to the right as you do from the right to left. Even in this situation things are still going to be moving from left to right and right to left, but now that you have the same number on either side at any given moment, in any given period of time, you have an equal probability of things moving from the left to the right as you do from the right to the left, so you're getting to kind of this equilibrium situation. Sure, in a given, you know, if you take a certain unit of time, maybe that one moves from the left to the right, that one moves from the left to the right, that one moves from the left to the right, but since you have equal concentrations on both sides you're just as likely to have the same number move from right to left. And I only did this with 20, I only did this with 20 particles, which is a little bit of an artificially low number. If we're actually talking about concentrations of air molecules or as we'll see when we think about cellular membranes, if we think about different types of molecules that might be in an aqueous solution, we're talking about way more than 20 molecules and so you really do think in terms of probabilistic large numbers, well hey, the probability of something moving from the left to the right is the same as the right to left, and so you're going to have this stability. Right here there's a much higher probability in any given moment of something moving from left to right than right to left and that's why you see things moving from high concentration to low concentration. Or another way to think about it, what we just observed here is we saw things diffusing down their conf--, down their concentration gradient. So this process that we just described, this is diffusion, this is diffusion, and as we study different types of systems we'll see that this is actually very important to biological systems and even chemical systems because this doesn't require any extra energy to move the molecules from here to there, it's going to happen probabilistically, it's going to happen naturally and once again, no magic, just more stuff here, higher chance moving from left to right than moving from right to left. And I really want to make that point clear. You can still move from right to left, for example you might have this character, maybe his, maybe instead of moving in that direction completely possible, completely possible that he goes from right to left. It's not like everything is moving from left to right but you have a higher chance, you're going to have more things moving from left to right, so that guy could move in that direction because there's just more stuff here. They're all bouncing around in all, in all different, in all different random directions.