Health and medicine
Created by Matthew Barry Jensen.
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- Why do the senses of pain and temperature travel in slower axons? Shouldn't they be reaching the brain first because they are urgent?(62 votes)
- There is also the fact that reflex arcs exist for acute stimuli. Putting your hand on the stove results in you pulling your hand away due to the arc and not because of the signal to the brain itself(32 votes)
- I understand that pain and temperature stimuli travel along slow somatosensory neurons from the PNS to the CNS. But why is it that when you accidentally touch something very hot (like a boiling pot), you reflexively pull away? It takes a second for you to feel the pain and the heat consciously, and yet, before you're aware of those things, your hand pulls away. Is this a reflex? I watched the muscle reflex video following this video, but that doesn't seem to apply here. If nociceptors and thermoreceptors are attached to slow neurons, why the immediate response? Are the mechanoreceptors used for fine-touch sense involved in this? Or am I overestimating the speed of the response, and in reality it's slower, and in direct response to the temperature and pain stimuli and nothing else?(19 votes)
- Pain stimuli can use the reflex response where the response is mediated by interneurons in the CNS and does not need to travel all the way to the brain for processing in order to react.(33 votes)
- How do small-diameter axons without a myelin sheath transmit any information at all? Wouldn't the signal die out?(10 votes)
- Emma, to clarify, what you're talking about is the all-or-none principle of neuron firing of an action potential.
Saltatory conduction because of myelin does help axons transmit stronger signals faster.
Electrotonic spread through the neuron does dissipate which is why your signal needs to be boosted at the Nodes of Ranvier by ion pumps.
The signal doesn't dissipate, like Emma said, but is just slower.(7 votes)
- My question is about the anatomy and direction of the action potential in somatosensory neurons. It seems that the action potential starts at the receptors (pain, position, etc.) then goes to the soma, which is opposite to the direction I learned about in previous videos about generation of an action potential. Does the axon hillock not play a role in generating action potentials in somatosensory neurons? Do dendrites exist in these neurons? If so, are they near the somatosensory receptors in the periphery?(11 votes)
Sensory neurons have a slightly different structure than the typical neuron, this image helped me visualize where the axon and soma are in a sensory neuron!(3 votes)
I don't understand what you define by "Touch", Could you be more precise ? it seems it gathers a lot of different things.
Personally I would have put vibration as a subcategory of touch, and pain also (some kind of extreme version of touch that is causing damage to skin).
- I am also confused in the same way you are, but my guess is that he might mean "pressure" instead of touch, because I've heard that there are specific neurons to sense pressure. I heard an example that what our brain interprets to be "wet" is actually a combination of the sensation of cool temperature WITH the sensation of gentle pressure (the kind of subtle pressure liquid would cause as it clings to the skin), which is why sometimes when something cold touches us gently, we perceive it as "wet" initially even if it is completely dry.
Can anyone else confirm or correct that his use of "touch" may mean "pressure"?(7 votes)
- As was mentioned the ends of the noiceptors do not have any covering at the terminal point. My first question is how does the action potential start and secondly is the final portion of these nerves constructed in a particular manner?(3 votes)
- The voltage gated sodium channels are located in the area of the axon closest to the skin as opposed to near the soma, allowing for the action potentials to reach the brain.(2 votes)
- Would afferent neurons have their somas in ganglia? If so, wouldn't that make most of the "milage" of the returning neuron dendritic instead of axonal?(3 votes)
- You are correct in thinking that the soma are in ganglia. Somatosensory neurons don't typically have dendrites, though. They are composed of the peripheral branch, the axon that goes out to the skin, and the central branch, or the axon that goes into the spinal cord.(1 vote)
- Hi, Can you please explain what is "fine touch sense" and "gross touch sense" as you mention towards the end of the video starting from8:58? Thank you.(2 votes)
- Fine touch refers to touch that is very small and centered (for example, touching a hair with the tip of your finger). Gross touch refers to touch that is larger (for example, feeling someone put their palm on your back).(3 votes)
- Around7:38- what is the benefit of having slower axons with thinner myelin sheaths? Does the slowness of pain/temperature receptors make us feel it less acutely?(1 vote)
- The benefit that should be emphasized Is for faster, skinny, myelinated axons, not slower unmyelinated ones. The author of this video does not explain this concept completely, he basically says myelinated axons are fast, unmyelinated axons are slow. If we look at snails and other more primitive creatures, we see only unmyelinated axons with comparatively slower action potentials. In vertebrates, a more complex range of animals, we see an 'upgrade' for selected axons to become myelinated. Being myelinated allows a skinny axon to carrying a fast action potential. The fastest axons are mylelinated skeletal muscle axons, so we can get out of the way of danger faster, and avoid, for example, a pouncing predator. Touch on the hands and face is typically also fast and precise because it is carried on myelinated axons so we can respond quickly. Unmyelinated axons would have to be much wider to be as fast as these myelinated axons.
Internal organ pain is slower, duller, and less easily localized because it is carried on unmyelinated axons. While organ pain is important and this dullness can put us at risk of ignoring life threatening pain, frankly, we have time to respond to that pain so the speed of the action potential is not as important. It is likely that the ability to get out of the way of the predator faster, allowed vertebrates to live longer and reproduce, so natural selection and evolution had a hand in this division between myelinated axons and unmyelinated axons in vertebrates.
So, in summary, our nervous system has a combination of myelinated and unmyelinated axons. It is the myelin that is the 'upgrade' , it promotes speed on narrow axons and allows faster responses by the animal. If our axons were all unmyelinated, like the snails, estimates are that the human spinal cord would have to be as wide as a 50 gallon barrel or the size of a thick "tree trunk" to have unmyelinated axons carrying action potentials as fast as our myelinated axons. Instead our spinal cord is about the width of your thumb, 2-3 cm, thanks to myelinated axons. (I will see if I can reference that last example as I know I read it somewhere. Yup, NIH comes through..) https://www.ncbi.nlm.nih.gov/books/NBK27954/(4 votes)
- At5:20to 6.06 he mentions information being passed from receptors to the CNS via the axons of afferent neurons and that the somas of these neurons are located in ganglia by the spinal cord or brain stem. I learned that information in neurons was passed from dendrites -> soma -> axon -> axon terminal, but is that not the case here? Can information also be passed from an axon terminal -> axon -> another axon terminal?(2 votes)
- There are different ways that the information can be passed. Some are more common than others, but they exist nonetheless. For example, information can be passed from axon-to-axon (axoaxonic synapse), which will result in the information travelling in the latter manner that you mentioned. It can also be dendrite-to-soma, dendrite-to-dendrite, dendrite-to-axon. The important thing is if the stimulus is strong enough to cause an action potential.(1 vote)
Voiceover: In this video, I'm going to talk about somatosensation in the peripheral nervous system. Somatosensation refers to senses of the body. That includes a whole bunch of different senses, but I like to think about five senses in particular, which turn out to be really useful for medical purposes because we can test them on examination. The first of these we call position sense, by which we mean the position of body parts relative to each other. For example, if you close your eyes and somebody lifts your arm above your head, you can feel that your arm has been moved. You don't actually have to see it to know that. Another sense of the body is vibration sense. If we come into contact with anything that's vibrating we can feel that. We often use little tuning forks when we're examining patients, to see if they have normal ability to feel something vibrating. The next sense is touch. I'm going to write that in a different color, and I'll come back to why I'm using these different colors in a minute. Then we have pain and temperature. Temperature. Let me just write a little "R" here to represent a receptor for one of these types of somatosensation, because to be able to sense anything, you need a receptor. Something that can detect that type of stimulus. There are many different types of somatosensory receptors, and we lump them into a few different categories. The first big category of somatosensory receptors respond to physical forces, so we call those mechanoreceptors, because they respond to mechanical stimuli. Mechanoreceptors. Receptors in the category of mechanoreceptors can detect the position of body parts, relative to each other, and vibration, and touch. Then there are other receptors for the senses of pain and temperature, which I'll just represent with a bit "R" here. Somatosensory receptors that can detect noxious stimuli, that can create the experience of pain, we call nociceptors. Nociceptors. They actually can detect a number of different types of stimuli that can give rise to the experience of pain, and then somatosensory receptors that can detect temperature we call thermoreceptors. Thermoreceptors. Somatosensory receptors, and all these different categories, can be found in a number of places throughout the body. One of the big places is in the skin. Here's a drawing of the skin. This is the very surface of the skin, with the hair coming out of it, and then here are the deeper layers of the skin. There are a number of neuron axons entering the skin here in a few different places, that will have some of these different somatosensory receptor types. For example, for mechanoreceptors, in this drawing there are a couple of mechanoreceptors drawn, and they tend to have these structures on the end. For instance, right here, this little structure on the end of this axon that's coming into the skin, that's one type of mechanoreceptor, close to the surface of the skin, and here's another type of mechanoreceptor, with this structure here at the end, of this axon that's coming into the skin. These are two types of mechanoreceptors that can be found in the skin, and there's lots of different types of mechanoreceptors in the skin that sense all sorts of mechanical stimuli to the skin, but there are also somatosensory receptors in the deep tissues, way below the skin here. For example, in this drawing, here is a muscle. This is one skeletal muscle. In this illustration they've magnified one somatosensory receptor that's in the muscle. It's this whole structure right here, and this particular somatosensory receptor is a mechanoreceptor that detects stretch of skeletal muscle, so when this skeletal muscle is stretched, this receptor can detect that and send that information back to the central nervous system, through neurons. These types of receptors, like this one in muscle, along with other ones in tendons and in the capsules around joints, are very important for position sense, because they can send information back to the nervous system about the relative position of body parts, whereas some of these mechanoreceptors in the skin or the tissues just closer to the skin are often more important for detecting things like vibration and touch. Nociceptors that detect pain and thermoreceptors that detect temperature usually don't have these sorts of structures at the end of an axon that's going to carry that information back to the central nervous system. Instead they're usually like they've drawn here, where there is an axon coming into the skin, right here, and at the end there is no structure. The axon just ends in some uncovered terminals. Let me circle that here. These are usually called bare nerve endings, because they are not covered by any kind of structure, like these guys are. Nociceptors, detecting noxious stimuli that can cause pain, and thermoreceptors, detecting temperature, tend to be these bare nerve endings. Once one of these somatosensory receptors detects the stimuli that it's specific for, it's going to send that information back in axons, up the peripheral nervous system, and these are going to be axons carrying information from the periphery, through nerves in the peripheral nervous system, back into the central nervous system. These are a type of afferent neuron, carrying information into the central nervous system. These afferent neurons, carrying somatosensory information, we call somatosensory neurons. Most of these neurons have their somas in ganglia close to either the spinal cord, or, if they're entering the brainstem, their somas will be in ganglia close to the brainstem. The different types of somatosensory information tends to travel in different types of somatosensory neurons, so that position sense information, vibration sense information, and some of the touch information, tends to travel in certain somatosensory neurons, like I've drawn here in blue, while pain information, temperature information, and the rest of the touch information tends to travel in different types of somatosensory neurons that also bring information back to the central nervous system. One of the big differences between these different types of somatosensory neurons is how big their axon is, and how much myelin there is on the axon, so that this type of somatosensory neuron carrying information about position sense, vibration sense and some touch sense, tends to be in large-diameter axons. Let me just draw a couple of lines, far apart, to represent a large-diameter axon. These axons tend to have thick myelin sheaths. The Schwann cells, that are creating the myelin sheaths on these somatosensory axons, tend to be wrapped around with many, many layers, so that they're very thick. I'll just draw these orange circles, to represent the thick myelin sheath on this type of somatosensory axon, whereas these other types of somatosensory neurons carrying the pain and temperature information, as well as the rest of the touch information, tend to have small-diameter axons. Let me just draw a much thinner axon here, like this. Let me draw two of these, actually. They're both going to have these thinner neuron axons, with a smaller diameter. Then they'll either have a thin myelin sheath, so let me just write some thinner circles here, to represent a thinner myelin sheath, with less wrapping of Schwann cell membranes around the axon of these somatosensory neurons, or they'll have no myelin sheath at all. They will be unmyelinated axons. Since axons with a larger diameter and a thicker myelin sheath conduct action potentials more rapidly, these types of somatosensory neurons will conduct action potentials fast, whereas the somatosensory neurons that have small-diameter axons and thin myelin sheaths, or no myelin sheath at all, will conduct action potentials more slowly. That information will get there, but it'll take a longer time to get back from the receptor in the periphery, to the central nervous system. The sense of touch is a funny one, because it travels in both, these rapid somatosensory neurons, and these slower somatosensory neurons. What tends to happen is that very precise touch information, that we call the fine touch sense, tends to travel in the fast somatosensory neurons, whereas less precise touch information, that we usually call gross touch sense, tends to travel in the slower somatosensory neurons. In later videos we'll get more into somatosensation, in terms of what happens to this information once it gets into the central nervous system, but this is a general overview of how somatosensation occurs in the peripheral nervous system.