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Changes in signal transduction pathways

AP.BIO: IST‑3 (EU), IST‑3.G (LO), IST‑3.G.1 (EK), IST‑3.G.2 (EK)

Problem

Mutations within genes coding for G protein-coupled receptors (GPCRs) can lead to one of two major outcomes—a loss-of-function or a gain-of-function. Loss-of-function mutations prevent signaling in GPCR pathways, even in the presence of signaling molecules. Gain-of-function mutations activate signaling in GPCR pathways, even in the absence of signaling molecules.
Which of the following is most likely to result from a loss-of-function GPCR mutation?
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