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Atrial fibrillation (Afib)

Created by Bianca Yoo.

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  • purple pi purple style avatar for user Residuum
    Is there any treatment of Afib? Blood thinners are mentioned for control, but are there any medical options for someone who has this?
    (3 votes)
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    • spunky sam blue style avatar for user Brian Collins
      Anticoagulants are just a part of the overall treatment of A-fib in that there are certain goals in patient management:
      1) control ventricular response (rate control)
      2) prevent thromboembolism (where anticoags come into play)
      3) restore normal sinus rhythm (rhythm control)
      4) prevent further recurrences of the A-fib (either with medication or with radiofrequency catheter ablation).
      (6 votes)
  • orange juice squid orange style avatar for user Kutili
    If a patient with AFib is treated with blood thinner medication, how do you prevent bleeding?
    (2 votes)
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    • spunky sam blue style avatar for user Brian Collins
      bleeding is a risk of any anticoagulant therapy, but there is what's called a "therapeutic window" in terms of clotting function where the likelihood of developing a blood clot is significantly reduced while still permitting the formation of clots in response to tissue injury. the clotting process is a very complicated, multi-factorial process that can be affected by many different variables, and this is why patients taking warfarin need regular lab visits to ensure they're still in their therapeutic window. On a side note, this is one reason why the "next generation" anti-coagulants are such a big deal for patients - they don't have to do the routine blood draws because their anticoagulant effect is more predictable.
      (2 votes)
  • primosaur seed style avatar for user robertold2013
    Hello good video, I have a question, what is the difference between irregularly irregular rhythm and irregularly regular rhythm?
    (2 votes)
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    • blobby green style avatar for user Triple Kevin
      Irregular means the R-R value isn't the same every beat.

      Irregularly irregular means that the R-R is completely irregular with no associated pattern.

      Regularly irregular means that there is an associated pattern to the irregular R-R.

      A good example of a regularly irregular rhythm would be Winkebach's / Mobitz type 1.
      (1 vote)
  • leafers seed style avatar for user Salma Dawoud
    Does this mean its an issue with the SA node
    (2 votes)
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    • leafers ultimate style avatar for user tartan.handbag
      There are multiple theories about the etiology of atrial fibrillation. An important theory is that, in atrial fibrillation, the regular impulses produced by the sinus node for a normal heartbeat are overwhelmed by rapid electrical discharges produced in the atria and adjacent parts of the pulmonary veins. Sources of these disturbances are either automatic foci, often localized at one of the pulmonary veins, or a small number of localized sources in the form of either reentrant electrical spiral waves (rotors) or repetitive focal beats; these localized sources may be found in the left atrium near the pulmonary veins or in a variety of other locations through both the left or right atrium.

      Because recovery of the atria from excitation is heterogeneous, the electrical waves generated by the AF sources undergo repetitive, spatially distributed breakup and fragmentation in a process known as "fibrillatory conduction". Another theory is the multiple wavelet theory first formulated by Moe,[20] which was experimentally proven by Allessie et al.

      AF can be distinguished from atrial flutter (AFL), which appears as an organized electrical circuit usually in the right atrium. AFL produces characteristic saw-toothed F-waves of constant amplitude and frequency on an ECG whereas AF does not. In AFL, the discharges circulate rapidly at a rate of 300 beats per minute (bpm) around the atrium. In AF, there is no regularity of this kind, except at the sources where the local activation rate can exceed 500 bpm.

      Although the electrical impulses of AF occur at a high rate, most of them do not result in a heart beat. A heart beat results when an electrical impulse from the atria passes through the atrioventricular (AV) node to the ventricles and causes them to contract. During AF, if all of the impulses from the atria passed through the AV node, there would be severe ventricular tachycardia, resulting in severe reduction of cardiac output. This dangerous situation is prevented by the AV node since its limited conduction velocity reduces the rate at which impulses reach the ventricles during AF.[21]

      from: https://en.wikipedia.org/wiki/Atrial_fibrillation#Electrophysiology
      (1 vote)
  • aqualine sapling style avatar for user Jennifer.Bibi94
    What are the typical signs that shows someone has AFib or someone with a dysrhythmia?
    (1 vote)
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    • leaf blue style avatar for user dysmnemonic
      The main examination sign for AF is that the pulse is irregularly irregular - there's no clear pattern to when heartbeats happen, because the ventricular contractions are set of almost at random by the constant electrical activity in the atria.
      (2 votes)
  • piceratops seed style avatar for user alexandre babrour
    aren't pulmonary veins the main cause of A fib ?
    (1 vote)
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    • leafers ultimate style avatar for user tartan.handbag
      There are multiple theories about the etiology of atrial fibrillation. An important theory is that, in atrial fibrillation, the regular impulses produced by the sinus node for a normal heartbeat are overwhelmed by rapid electrical discharges produced in the atria and adjacent parts of the pulmonary veins. Sources of these disturbances are either automatic foci, often localized at one of the pulmonary veins, or a small number of localized sources in the form of either reentrant electrical spiral waves (rotors) or repetitive focal beats; these localized sources may be found in the left atrium near the pulmonary veins or in a variety of other locations through both the left or right atrium.

      Because recovery of the atria from excitation is heterogeneous, the electrical waves generated by the AF sources undergo repetitive, spatially distributed breakup and fragmentation in a process known as "fibrillatory conduction". Another theory is the multiple wavelet theory first formulated by Moe,[20] which was experimentally proven by Allessie et al.

      AF can be distinguished from atrial flutter (AFL), which appears as an organized electrical circuit usually in the right atrium. AFL produces characteristic saw-toothed F-waves of constant amplitude and frequency on an ECG whereas AF does not. In AFL, the discharges circulate rapidly at a rate of 300 beats per minute (bpm) around the atrium. In AF, there is no regularity of this kind, except at the sources where the local activation rate can exceed 500 bpm.

      Although the electrical impulses of AF occur at a high rate, most of them do not result in a heart beat. A heart beat results when an electrical impulse from the atria passes through the atrioventricular (AV) node to the ventricles and causes them to contract. During AF, if all of the impulses from the atria passed through the AV node, there would be severe ventricular tachycardia, resulting in severe reduction of cardiac output. This dangerous situation is prevented by the AV node since its limited conduction velocity reduces the rate at which impulses reach the ventricles during AF.[21]

      from: https://en.wikipedia.org/wiki/Atrial_fibrillation#Electrophysiology
      (1 vote)

Video transcript

- Atrial fibrillation is a heart arrhythmia more commonly know as AFib. It's one of the supraventricular tachycardias. In a normal heart, electrical wavelengths are conducted from the SA node to the AB node in an organized fashion. And since you have organized conduction going from the SA node to the AV node you're going to get concentric or unified contraction of the atrial tissue. However, in AFib wavelengths are in disarray. So notice how they're all erratic and going everywhere. Because you lose this organized signal, you're not going to have unified contraction of the atria, instead with these erratic wavelengths you're going to have atrial spasming. It actually kinds of looks like there's a bag of worms in the atria and they're all moving around, if you can imagine that. Also the wavelengths are doing their own things, so they're going to be signaling the AV node erratically and this is going to lead to an irregular rhythm, because of the irregular stimulation. Classically the AFib EKG is said to be irregularly irregular. What does that mean? Well notice how the distance between the R-R intervals is different with each beat. In a normal heart it's the evenly spaced R-R intervals. With AFib you have different distances between the R and the R intervals. Also in AFib there are no distinct P-waves on EKG. Instead you have the coarse squiggly lines running through. But there are no distinct P-waves, that's because remember the atria is spasming. So you're not going to get that nice unified concentric contraction of the atria, so you have these coarse squiggly lines instead representing the atrial spasm. What are the risk factors for atrial fibrillation? Well anyone that had diseased atrial tissue has an increased risk for AFib. And how does atrial tissue become diseased? Well, with old age, so the skin in your body tends to get old with age, so does your atrial tissue. Also anything that causes the tissue of the atria become inflamed can cause atrial fibrillation. So imagine if you just had a recent heart procedure that causes inflammation, that will increase your risk for atrial fibrillation and anything that causes atrial enlargement. This includes years of high blood pressure and also certain types of valve disease like mitral stenosis, certain types of lung dissease and previously having AFib can enlarge your atria. Other things that increase your risk, include certain hormonal abnormalities specifically your thyroid hormone and years of alcohol abuse. It's also worth mentioning that people who have AFib are at an increased risk for having strokes. So these people are typically put on some sort of blood thinner medication. Now why are these people at a higher risk for stroke? When the atria is spasming blood is going to pool in the atrium. When the atrial tissue is spasming, blood then pools in the atria and it doesn't move. And what happens to blood that doesn't move? It clots. Now imagine, so I'm drawing a big clot right here, and imagine if this clot escaped the atrium, went to the ventrical, and then out to the rest of the circulation, it could go to other organs, including the brain. and if a clot goes to a blood vessel that supplies the brain, well that can lead to stroke. Therefore, people who have had AFib are usually put on blood thinners which will help prevent clot formation and thereby reduce the risk of certain kinds of strokes.